解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7908
更新日期:2005-08-01 00:00:00
abstract::The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章
doi:10.1289/ehp.7814
更新日期:2005-08-01 00:00:00
abstract::Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7713
更新日期:2005-08-01 00:00:00
abstract::Asthma and lead poisoning are prevalent among urban children in the United States. Lead exposure may be associated with excessive production of immunoglobulin E, possibly increasing asthma risk and contributing to racial disparities. The objective of this study was to examine racial differences in the association of b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7453
更新日期:2005-07-01 00:00:00
abstract::New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7651
更新日期:2005-07-01 00:00:00
abstract::Exposure to environmental pollutants may contribute to the development of coronary heart disease (CHD). We determined the ZIP codes containing or abutting each of the approximately 900 hazardous waste sites in New York and identified the major contaminants in each. Three categories of ZIP codes were then distinguished...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7595
更新日期:2005-06-01 00:00:00
abstract::Although broad links between climatic factors and coccidioidomycosis have been established, the identification of simple and robust relationships linking climatic controls to seasonal timing and outbreaks of the disease has remained elusive. Using an adaptive data-oriented method for estimating date of exposure, in th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7786
更新日期:2005-06-01 00:00:00
abstract::Preterm delivery can lead to serious infant health outcomes, including death and lifelong disability. Small increases in preterm delivery risk in relation to spatial gradients of air pollution have been reported, but previous studies may have controlled inadequately for individual factors. Using a time-series analysis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7646
更新日期:2005-05-01 00:00:00
abstract::The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.7544
更新日期:2005-05-01 00:00:00
abstract::We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7559
更新日期:2005-04-01 00:00:00
abstract::The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7375
更新日期:2005-04-01 00:00:00
abstract::Stable associations of syntrophic fermentative organisms and populations that consume fermentation products play key roles in the anaerobic biodegradation of chlorinated organic contaminants. The involvement of these syntrophic populations is essential for mineralization of chlorinated aromatic compounds under methano...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6933
更新日期:2005-03-01 00:00:00
abstract::Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7519
更新日期:2005-03-01 00:00:00
abstract::The Children's Post-Pesticide Application Exposure Study (CPPAES) was conducted to look at the distribution of chlorpyrifos within a home environment for 2 weeks after a routine professional crack-and-crevice application and to determine the amount of the chlorpyrifos that is absorbed by a child living within the home...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6984
更新日期:2005-02-01 00:00:00
abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7467
更新日期:2005-02-01 00:00:00
abstract::New technologies are providing innovative ways to reduce sound levels in many areas. Aircraft engineers are finding ways to reduce the noise produced by jet engines, while road builders are using rubber-enhanced pavement to quiet highway noise. Indoor acoustics are benefiting from materials that transform sound waves ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.113-a46
更新日期:2005-01-01 00:00:00
abstract::Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7475
更新日期:2005-01-01 00:00:00
abstract::Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastroin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7259
更新日期:2005-01-01 00:00:00
abstract::Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7209
更新日期:2004-12-01 00:00:00
abstract::Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7234
更新日期:2004-12-01 00:00:00
abstract::A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using the rodent uterotroph...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/txg.7345
更新日期:2004-11-01 00:00:00
abstract::Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7155
更新日期:2004-11-01 00:00:00
abstract::Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is important, we have previously shown that a phytoestrogen-rich diet and a phytoestrogen-free diet...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7039
更新日期:2004-11-01 00:00:00
abstract::The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contam...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7145
更新日期:2004-10-01 00:00:00
abstract::We measured volatile organic compound (VOC) exposures in multiple locations for a diverse population of children who attended two inner-city schools in Minneapolis, Minnesota. Fifteen common VOCs were measured at four locations: outdoors (O), indoors at school (S), indoors at home (H), and in personal samples (P). Con...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7107
更新日期:2004-10-01 00:00:00
abstract::Environmental health is a subject that has only relatively recently become prominent in the social consciousness. Even as its significance becomes known, finding ways to integrate the subject into education for primary and secondary students is difficult because of federal testing requirements under the No Child Left ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.112-a814
更新日期:2004-10-01 00:00:00
abstract::Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6901
更新日期:2004-09-01 00:00:00
abstract::Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6980
更新日期:2004-09-01 00:00:00
abstract::Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/txg.7036
更新日期:2004-08-01 00:00:00
abstract::There are still many uncertainties regarding the risk of adverse pregnancy outcomes associated with exposure to drinking water disinfection by-products. In Montréal, Québec, Canada, we carried out a hospital-based case-control study including 493 cases of intrauterine growth restriction defined as birth weight below t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7003
更新日期:2004-08-01 00:00:00
abstract::The purpose of this study was to examine whether perinatal exposure to two major environmental endocrine-disrupting chemicals, bisphenol A (BPA; 0.1 mg/kg/day orally) and nonylphenol [NP; 0.1 mg/kg/day (low dose) and 10 mg/kg/day (high dose) orally] daily from gestational day 3 to postnatal day 20 (transplacental and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6961
更新日期:2004-08-01 00:00:00
abstract::Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6923
更新日期:2004-07-01 00:00:00
abstract::Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clus...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.6735
更新日期:2004-06-01 00:00:00
abstract::We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6869
更新日期:2004-06-01 00:00:00
abstract::We examined 100 symptomatic Gulf War veterans (patients) and 100 controls for immunologic assays. The veterans and controls were compared for the percentage of T cells (CD3); B cells (CD19); helper:suppressor (CD4:CD8) ratio; natural killer (NK) cell activity; mitogenic response to phytohemagglutin (PHA) and pokeweed ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6881
更新日期:2004-06-01 00:00:00
abstract::Phthalates are a group of multifunctional chemicals used in consumer and personal care products, plastics, and medical devices. Laboratory studies show that some phthalates are reproductive and developmental toxicants. Recently, human studies have shown measurable levels of several phthalates in most of the U.S. gener...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6804
更新日期:2004-05-01 00:00:00
abstract::Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章
doi:10.1289/ehp.6766
更新日期:2004-05-01 00:00:00
abstract::Virginia Bioinformatics Institute, in conjunction with National Institutes of Environmental Health Sciences, hosted a conference, "Toxicogenomics through the Eyes of Informatics," in Bethesda, Maryland, USA, on 12-13 May 2003. Researchers around the world met to discuss how the application of bioinformatics tools, met...
journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.112-1241996
更新日期:2004-05-01 00:00:00
abstract::Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6542
更新日期:2004-04-01 00:00:00
abstract::Although para-nonylphenol (NP) is known as an endocrine disruptor, the immunologic effect of NP has been poorly analyzed. We found that NP from 5 to 50 microM caused a dose-dependent stimulatory effect on the generation of reactive oxygen species (ROS) in human blood neutrophils, which was measured by using a chemilum...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6584
更新日期:2004-04-01 00:00:00